Reduces dyspnea and increases exercise endurance for patients with COPD

Breathe Technologies’ wearable and open ventilation* decreases work of breathing (WOB), respiratory muscle activation, and dyspnea, allowing for improved exercise tolerance and 6-minute walk tests (6MWT) compared to traditional oxygen therapy.1-6

  • reduction in healthcare costs and healthcare utilization such as inpatient admissions and mechanical ventilation days7
  • reduction in patient-reported CAT and mMRC scores2
  • reduction in WOB1
  • 46% reduction in accessory respiratory muscle activation3
  • 28% reduction in Borg Dyspnea Scale3
  • 54% increase in exercise endurance from 11.4 to 17.5 minutes (P < .001)3
  • 34 to 73 m improvement in 6MWT distance4,5
  • 85% improvement in ability to perform activities of daily living6

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Impact of improving mobility and activity levels

  • Activity for 2 hours a week reduces hospital admissions and respiratory mortality by 30% to 40%, according to a 20-year follow-up study of 2,386 subjects with COPD8
  • Outdoor activity increases 4-year survival 35% versus 15% for oxygen-dependent patients9
  • Physical activity is the best predictor of all-cause mortality in COPD patients; for every 0.14 decrease in physical activity level (PAL), the relative risk of death is more than doubled10

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*The data presented are reflective of studies performed on open ventilation technology.

References

1. Siobal M, Marelowe J. Work of breathing using non-invasive open ventilation in a low compliance high minute ventilation lung model. [abstract]. AARC 2015. 2. Carlin BW, Casey L, Farberow K. Improvement in health status of patients with respiratory insufficiency with the use of a noninvasive open ventilation system. Chest. 2014;146(4 MeetingAbstracts):341A. 3. Porszasz J, Cao R, Morishige R, et al. Physiologic effects of an ambulatory ventilation system in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(3):334–342. 4. Hilling L, Cayou C, Wondka T, Kops R. Improved 6MWT distance with a highly portable non-invasive ventilator [abstract]. Am J Respir Crit Care Med. 2010;181:A1198. 5. Garvey C, Hilling L, Cayou C, Escobar R, Heron G, McCabe L. Open, noninvasive ventilation using a 1 lb ventilator, oxygen, and a low profile mask improves 6MWT distances in advanced COPD [abstract]. Am J Respir Crit Care Med. 2011;183:A3971. 6. Carlin BW, Wiles KS, McCoy RW, et al. Effects of a highly portable noninvasive open ventilation system on activities of daily living in patients with COPD. J COPD F. 2015;2(1):35-47. 7. Morishige R, Farberow K, MacIntyre N. Health care utilization and respiratory health status in patients with chronic respiratory insufficiency following addition of a portable noninvasive ventilator to the treatment regimen. Chest. 2015;148(4 MeetingAbstracts):908A. 8. Garcia-Aymerich J, Lange P, Benet M, et al. Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population-based cohort study. Thorax. 2006;61:772-778. 9. Ringbaek TJ, Lange P. Outdoor activity and performance status as predictors of survival in hypoxaemic chronic obstructive pulmonary disease (COPD). Clin Rehabil. 2005;19(3):331-338. 10. Waschki B, Kirsten A, Holz O, et al. Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study. Chest. 2011;140(2):331-342.

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